DEXAJECT – 200

Thành phần:

Dexamethasone Sodium Phosphate: 1mg/m

Công dụng:

Chống viêm, chống dị ứng, chống shock

DEXAJECT – 200

Injectable solution

For Veterinary Use Only

 

Composition:

In 1 ml contains:

Dexamethasone Sodium Phosphate 2 mg

 

Indications:

Dexamethasone is a synthetic corticosteroid with potent anti-inflammatory action. DEXAJECT-200 can be used for:

• Intravenous therapy in cases where emergency treatment is indicated, particularly shock and circulatory collapse, fog fever, acute mastitis and
• Acetonaemia (ketosis) in cattle. DEXAJECT-200 has a marked glucogenic action.
• Inflammatory conditions in all species: DEXAJECT-200 will suppress inflammation and is indicated in the treatment of arthritis, dermatitis

 

Contraindications:

Do not use in patients with renal disease and diabetes mellitus.

 

 

Dosage and administration:

By intravenous or intramuscular injection. Normal aseptic precautions should be observed. Recommended Dosage Schedule:

Horses and cattle:     1 ml per 25 kg bodyweight (0.08 mg dexamethasone per kg body weight) Dogs and cats:       1 ml per 10 kg body weight (0.2 mg dexamethasone per kg body weight)

e.g

Horses 500 kg:         20 ml

Cattle 400 kg:      16 ml

Dogs 10 kg:   1 ml

Cats 5 kg:     0.5 ml

 

Side effects:

Anti-inflammatory corticosteroids such as dexamethasone, are known to exert a wide range of side- effects. Whilst single high doses are generally well tolerated, they may induce severe

side-effects in long term use and when esters possessing a long duration of action are administered.

Dosage in medium to    long-term use should therefore generally be kept to the

minimum necessary to control symptoms. In the presence of bacterial infection, antibacterial drug cover is usually required when steroids are used.

 

Adverse reactions (frequency and seriousness)

Steroids themselves, during treatment, may cause Cushingoid symptoms involving significant alteration of fat, carbohydrate, protein and mineral metabolism e.g. redistribution of body fat, muscle weakness and wastage and osteoporosis may result. During therapy effective doses suppress the

 

Hypothalamo-Pituitreal-Adrenal axis. Following cessation of treatment, symptoms of adrenal insufficiency extending to adrenocorticol atrophy can arise and this may render the animal unable to deal adequately with stressful situations. Consideration should therefore be given to means of minimizing problems of adrenal insufficiency following the withdrawal of treatment, e.g. a gradual reduction of dosage (for further discussion see standard texts).

Systemically acting corticosteroids may cause polyuria, polydipsia and polyphagia, particularly during the early stages of therapy. Some corticosteroids may cause sodium and water retention and hypokalaemia in long-term use.

Systemic corticosteroids have caused deposition of calcium in the skin (calcinosis cutis). Corticosteroids may delay wound healing and the immunosuppressant actions may weaken resistance to or exacerbate existing infections.

Gastrointestinal ulceration has been reported in animals treated with corticosteroids and gastrointestinal tract ulceration may be exacerbated by steroids in patients given non-steroidal anti- inflammatory drugs and in corticosteroid-treated animals with spinal cord trauma. Steroids may cause enlargement of the liver (hepatomegaly) with increased serum hepatic enzymes. In the presence of viral infections, steroids may worsen or hasten the progress of the disease.

 

Use during pregnancy, lactation :

Corticosteroids are not recommended for use in pregnant animals. Administration in early pregnancy is known to have caused foetal abnormalities in laboratory animals. Administration in

late pregnancy may cause early parturition or abortion.

 

Withdrawal times:

Cattle and horses must not be slaughtered for human consumption during treatment. Cattle and horses may be slaughtered for human consumption only after 21 days from the last treatment. Milk must not be taken for human consumption during treatment. Milk for human consumption may be taken from cows only after 72 hours from the last treatment.

 

Storage conditions:

Store dark and below 25°C. Do not freeze.

 

 

Packing:

100 ml vials.