DOMEX

Thành phần: 

Doramectin: 10mg/ml

Công dụng:

Trị nội – ngoại kí sinh trùng

Injectable solution Long acting

 

PRODUCT CHARACTERISTICS

DOMEX is a long-acting, injectable, broad-spectrum parasiticide for cattle, sheep, goats and swine. One low-volume injection effectively controls a wide range of roundworm of cattle, sheep, goats and pigs as well as arthropod parasites of cattle, sheep, and pigs, which impair their health and productivity. DOMEX injectable solution is well-tolerated, has excellent syringeability and has a long action, making it particularly suitable for controlling parasites in cattle, sheep, goats and swine.

 

STORAGE CONDITIONS

Store below 30 ° C. Protect contents from light.

 

COMPOSITION

Doramectin 1%

 

PRODUCT DESCRIPTION

DOMEX injectable solution contains doramectin. Doramectin is a novel, fermentation-derived product of avermectin class of highly active, broad- spectrum antiparasitic agents. Doramectin is isolated from fermentations of a genetically altered strain of Streptomyces avermitilis.

DOMEX is a ready-to-use, sterile solution containing 1 % (10 mg/ml) doramectin. It is formulated to deliver the recommended dosage for cattle, sheep and goats (200 µg/ kg body mass) when given by either intramuscular or subcutaneous injection at the rate of 1 ml/ 50 kg body mass and for swine (300 µg/kg body mass) when given by intramuscular injection at the rate of 1 ml/ 33 kg body mass.

 

MODE OF ACTION

The primary mode of action for avermectins, the family of compounds to which doramectin belongs, is to modulate chloride ion channel activity in the nervous system of nematodes and arthropods. Avermectins bind to receptors that increase membrane permeability to chloride ions. This inhibits the electrical activity of nerve cells in nematodes and muscle cells in arthropods, and causes paralysis and death of the parasites. In mammals the neuronal receptors to which avermectins bind are localised within the central nervous system. Since doramectin does not readily penetrate the mammalian CNS it has a wide margin of safety in animals when used as recommended.

 

WARNINGS CATTLE

Animals may not be slaughtered for human consumption within 35 days of treatment. Do not use in cattle producing milk for human consumption.

SHEEP AND GOATS

Animals may not be slaughtered for human consumption within 35 days of treatment.

SWINE

Animals may not be slaughtered for human consumption within 28 days of treatment.

 

Keep out of reach of children and uninformed persons.

Although this remedy has been extensively tested under a large variety of conditions, failure thereof may ensue as a result of a wide range of reasons. If this is suspected, seek veterinary advice and notify the registration holder.

 

 

PRECAUTIONS

Sheep and goats should be vaccinated against pulpy kidney (enterotoxaemia) before treatment. Vaccination of cattle, sheep and goats against broad spectrum Clostridium infections (e.g. black quarter, malignant edema) is strongly recommended.

INDICATIONS

DOMEX  is a long-acting injectable solution indicated for the treatment and control of the following: gastro intestinal roundworms, parafilaria, screwworms, sucking lice, mange mites and single host ticks in cattle. Controls roundworms (Ascaris suum, Oesophagostomum dentatum, Oesophagostomum quadrispinulatum and Trichuris suis) and lung worms (Metastrongylus spp). It also kills sarcoptic mange mites and lice on pigs.

DOSAGE CATTLE

Administer DOMEX injectable solution at a dosage rate of 200 µg doramectin/ kg (1 ml/ 50 kg body mass). For easy reference, see table below:

 

MASS (kg)	DOSAGE (ml)	MASS (kg)	DOSAGE (ml)
50	1	251 – 300	6
51 – 100	2	301 – 350	7
101 – 150	3	351 – 400	8
151 – 200	4	401 – 450	9
201 – 250	5	451 – 500	10

 

SHEEP AND GOATS

Administer DOMEX injectable solution at a dosage rate of 200 µg/ kg doramectin (1 ml/ 50 kg) body mass or for sheep only 300 µg/ kg doramectin (1,5 ml/ 50 kg) body mass. For easy reference, see table below.

 

MASS (kg)	DOSAGE (ml) AT 1 ml / 50 kg	MASS (kg)	DOSAGE (ml) AT 1,5 ml / 50 kg
25	0,5	25	0,75
26 – 50	1	25 – 50	1,5
51 – 75	1,5	50 – 75	2,25
75 – 100	2	75 – 100	3

 

SWINE

Administer DOMEX injectable solution at a dosage rate of 300 µg doramectin/ kg (1 ml/ 33 kg) body mass. For easy reference, see table below.

 

MASS (kg)	DOSAGE (ml)	MASS (kg)	DOSAGE (ml)
33	1	201 – 233	7
34 – 67	2	234 – 267	8
68 – 100	3	268 – 300	9
101 – 133	4	301 – 333	10
134 – 167	5	334 – 367	11
168 – 200	6	368 – 400	12

 

ADMINISTRATION CATTLE

DOMEX injectable solution can be administered by the intramuscular or subcutaneous routes. Inject the product under soft skin in the neck or shoulder region or into the neck muscles.

SHEEP AND GOATS:

Administer DOMEX injectable solution by the intramuscular or subcutaneous route. Inject the product under soft skin in the neck or shoulder region or into the neck muscles.

SWINE

Administer DOMEX injectable solution by the intramuscular route. Animals should be restrained to ensure that treatment can be properly administered.